Poster Presentation 16th Lorne Infection and Immunity 2026

Title of my presentation for the conference is "Polydopamine based advanced drug delivery systems". (132688)

TAYYBA tayyba TARIQ 1
  1. Swinburne university of technology, hawthorn, VIC, Hawthorn, VIC, Australia

Advanced drug delivery systems are increasingly being explored to overcome the limitations of conventional therapeutics, such as instability, poor bioavailability, and uncontrolled release. Polydopamine (PDA), a bioinspired polymer with excellent biocompatibility, tuneable surface chemistry, and antioxidant properties, offers unique potential as a nanocarrier for multifunctional drug delivery. In this project, PDA particles were synthesized and investigated as carriers for ascorbic acid (vitamin C) and gentamicin, both individually and in co-loaded formulations. Vitamin C was selected due to its antioxidant and therapeutic benefits, while gentamicin, a broad-spectrum aminoglycoside antibiotic, was incorporated to provide antibacterial activity. The prepared pure and loaded PDA particles were subjected to physicochemical characterization, including size, morphology, surface charge, and encapsulation efficiency, to evaluate their suitability as delivery vehicles. Stability studies under light exposure, antioxidant activity assays, and preliminary release studies were also conducted to assess performance. By developing a PDA-based co-delivery system, this research aims to enhance the stability and bioactivity of vitamin C while enabling synergistic therapeutic outcomes with gentamicin. Overall, this work contributes to the advancement of bioinspired nanocarriers for multifunctional drug delivery, with potential applications in combating oxidative stress and bacterial infections.